Michael C. Hall (Dexter) stars as Tom Delaney, a widowed surgeon who begins unearthing dark secrets about the people closest to him after his teenage daughter goes missing.
Netflix unveiled a date-announcement trailer for the crime thriller based on the book by Harlan Coben, who serves as an executive producer.
The series also stars Amanda Abbington, Audrey Fleurot, Hannah Arterton, Emmett J. Scanlan, Marc Warren, Nigel Lindsay and Laila Rouass.
Safe premieres May 10.